Publications

  • Please click here for a PubMed list of publications.

  • Dose, M Gounari F. Fifty ways to Notch T-ALL Blood. 2008 Aug 1;112(3):457-8. PubMed PubMed Icon
  • Dose M, Khan I, Guo Z, Kovalovsky D, Krueger A, von Boehmer H, Khazaie K, Gounari F. c-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood. 2006 Oct 15;108(8):2669-77. Epub 2006 Jun 20. PubMed PubMed Icon
  • Guo Z, Dose M, Kovalovsky D, Chang R, O'Neil J, Look AT, von Boehmer H, Khazaie K, Gounari F. Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood. 2007 Jun 15;109(12):5463-72. Epub 2007 Feb 22. PubMed PubMed Icon
  • Garbe AI, Krueger A, Gounari F, Zúñiga-Pflücker JC, von Boehmer H. Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate. J Exp Med. 2006 Jun 12;203(6):1579-90. Epub 2006 Jun 5.
  • Mao C, Tili EG, Dose M, Haks MC, Bear SE, Maroulakou I, Horie K, Gaitanaris GA, Fidanza V, Ludwig T, Wiest DL, Gounari F, Tsichlis PN. Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. J Immunol. 2007 May 1;178(9):5443-53.
  • Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K. Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19977-82. Epub 2007 Dec 6.
  • Garbe AI, Krueger A, Gounari F, Zúñiga-Pflücker JC, von Boehmer H. Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate. J Exp Med. 2006 Jun 12;203(6):1579-90. Epub 2006 Jun 5.
  • Gounari F, Chang R, Cowan J, Guo Z, Dose M, Gounaris E, Khazaie K. Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol. 2005 Aug;6(8):800-9. Epub 2005 Jul 17.
  • Borowski C, Li X, Aifantis I, Gounari F, von Boehmer H. Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development. J Exp Med. 2004 Mar 1;199(5):607-15.
  • Martin CH, Aifantis I, Scimone ML, von Andrian UH, Reizis B, von Boehmer H, Gounari F. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol. 2003 Sep;4(9):866-73. Epub 2003 Aug 17.
  • von Boehmer H, Aifantis I, Gounari F, Azogui O, Haughn L, Apostolou I, Jaeckel E, Grassi F, Klein L. Thymic selection revisited: how essential is it? Immunol Rev. 2003 Feb;191:62-78. Review.
  • Li X., Gounari F., Protopopov A., Khazaie K., von Boehmer H. Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1. J Exp Med 205:2851-61 (2008).Hu M.G., Deshpande A., Enos M., Mao D., Hinds E.A., Hu G.F., Chang R., Guo Z., Dose M., Mao C., Tsichlis P. N., Gounari F., and Hinds P.W. A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and Tumorigenesis Cancer Res. 69: 810-818. (2009).Dose M, Sleckman B P, Han J, Bredemeyer A L, Bendelac A, and Gounari F. Intrathymic proliferation wave essential for V􏰀14􏰁 natural killer T cell development depends on c-Myc. Proc Natl Acad Sci USA 106:8641-8646 (2009).
  • Kovalovsky D., Yu Y., Dose M., Emmanouilidou A., Konstantinou T, Germar K., Aghajani K., Guo Z., Mandal M., and Gounari F. b-Catenin/TCF determines the outcome of thymic selection in response to abTCR signaling. The Journal of Immunology 183: 3873-3884 (2009).
  • T. Kreslavsky, A.K. Savage, R. Hobbs, F. Gounari, R. Bronson, P. Pereira, P.P. Pandolfi, A. Bendelac, and H. von Boehmer. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gd T cells with restricted TCR diversity. Proc Natl Acad Sci USA 106:12453-12458 (2009).
  • Gounaris E., Blatner N R., Dennis K., Magnusson F., Gurish M F., Strom T B., Beckhove P, Gounari F., and Khazaie K. T -Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis Cancer Res 69: 5490-5497 (2009).