Dr. Gounari's Lab Photo

We are interested in understanding the molecular mechanisms that govern lymphocyte development and transformation. Our studies are triggered by the desire to resolve the elaborate interplay between signaling pathways in lineage determination checkpoints along hematopoietic and lymphopoietic development. We are intrigued by the interconnection of ubiquitous evolutionary conserved cascades like WNT and Notch with more recent lineage specific pathways like pre-TCR, and αβTCR. These studies have the potential of providing an invaluable paradigm on the evolution of pathway interactions along a developmental process.