Publications


Please click here for a PubMed list of publications.

Peer Reviewed Articles

  • Goldman M, Abramowicz D, De Pauw L, Alegre ML, Widera I, Vereerstraeten P, Kinnaert P.  OKT3‑induced cytokine release syndrome: attenuation by high doses of methylprednisolone.  Lancet 2:802-803, 1989 (letter).
  • Alegre M, Vandenabeele P, Flamand V, Moser M, Leo O, Abramowicz D, Urbain J, Fiers W, Goldman M.  Hypothermia and hypoglycemia induced by anti‑CD3 monoclonal antibody in mice: role of TNF.  Eur. J. Immunol. 20:707-710, 1990.
  • Alegre M, Vincent JL.  Dopamine dependence in hypocalcemic patients.  Intensive Care Med. 16:463-465, 1990.
  • Alegre ML, Vandenabeele P, Depierreux M, Florquin S, Deschodt‑ Lanckman M, Flamand V, Moser M, Leo O, Urbain J, Fiers W, Goldman M.  Cytokine release syndrome induced by the 145‑2Cll anti‑CD3 monoclonal antibody in mice: prevention by high doses of methylprednisolone.  J. Immunol. 146:1184-1191, 1991.
  • Alegre ML, Depierreux M, Florquin S, Abramowicz D, De Pauw L, Kinnaert P, Vereerstraeten P, Goldman M.  Néphrotoxicité des anticorps monoclonaux anti‑CD3.  Néphrologie 12:42-45, 1991.
  • Alegre ML, Gastaldello K, Abramowicz D, Kinnaert P, Vereerstraeten P, Vandenabeele P, Moser M, Leo O, Goldman M.  Pentoxifylline reduces anti‑CD3 monoclonal antibodies‑induced cytokine release syndrome.  Transplantation 52:674-679, 1991.
  • Schandene L, Vandenbussche P, Crusiaux A, Alegre ML, Abramowicz D, Dupont E, Content J, Goldman M.  Differential effects of pentoxifylline on the production of TNF-a and IL-6 by monocytes and T cells.  Immunol. 76:30-34, 1992.
  • Woodle ES, Thistlthwaite JR, Joliffe LK, Zivin RA, Collins A, Adair JR, Bodmer M, Athwal D, Alegre ML, Bluestone JA.  Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression.  J. Immunol. 148:2756-2763, 1992.
  • Alegre ML, Collins AM, Pulito VL, Brosius RA, Olson WC, Zivin RA, Knowles R, Thistlethwaite JR, Jolliffe LK, Bluestone JA.  Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.  J. Immunol. 148:3461-3468, 1992.
  • Cozzi PJ, Padrid PA, Takeda J, Alegre ML, Yuhki N, Leff AR.  Sequence and functional characterization of feline interleukin 2.  Biochem. and Biophys. Res. Com. 194:1038-1043, 1993.
  • Pinski MR, Vincent JL, Devière J, Alegre M, Kahn RJ, Dupont E.  Serum cytokine levels in human septic shock. Relation to multiple-organ failure and mortality.  Chest 103:565-575, 1993.
  • Alegre ML, Peterson LJ, Xu D, Sattar HA, Jeyarajah DR, Kowalkowski K, Zivin RA, Knowles R, Jolliffe L, Thistlethwaite R, Bluestone JA.  A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivoTransplantation 57:1537-1543, 1994.
  • Alegre ML, Sattar HA, Herold KC, Smith J, Tepper MA, Bluestone JA.  Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by Deoxyspergualin in a murine model.  Transplantation 57:1786-1794, 1994.
  • Alegre ML, Peterson LJ, Jeyarajah RD, Kowalkowski K, Thistlethwaite JR, Bluestone JA.  Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts.  J. Immunol. 153:2738-2749, 1994.
  • Cozzi PJ, Tompkins M, Alegre ML, Takeda J, Leff AR.  Bioactivity of recombinant feline interleukin-2 on human and feline leukocytes.  Vet. Immunol. Immunopathol., 48:27-33, 1995.
  • Alegre ML, Sattar HS, Tso JY, Smith J, Desalle F, Cole M, Bluestone JA.  An anti-murine CD3 monoclonal antibody with a low affinity for Fcg-receptors suppresses transplantation responses while minimizing toxicity and immunogenicity.  J. Immunol. 155:1544-1555, 1995.
  • Marchant A, Alegre ML, Marecaux G, De Groote D, Goldman M. Production of IL-10 in patients with circulatory shock; role in monocyte dysfunction.  J. Clin. Immunol. 15:265-272, 1995.
  • Alegre ML, Noel PJ, Eisfelder,BJ, Chuang E, Clark MR, Reiner SL, Thompson CB.  Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J. Immunol., 157:4762-4770, 1996.
  • Chuang E, Alegre ML, Duckett CS, Noel PJ, Vanderheiden M, Thompson CB.  CTLA-4 interacts with the medium chain of clathrin associated proteins and undergoes clathrin mediated endocytosis.  J. Immunol. 159:144-151, 1997.
  • Mandal M, Chen X-R, Alegre ML, Chiu NM, Chen Y-H, Castano AR, Wang C-R.  Tissue distribution and biochemical characterization of murine CD1 molecules.  Molecular Immunol., 35:525-536, 1998.
  • Lin H, Rathmell JC, Gray GS, Thompson CB, Leiden JM, Alegre ML.  CTLA4 blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.  J. Exp. Med. 188:199-204, 1998.
  • Noel PJ, Alegre ML, Reiner SL, Thompson CB.  Impaired negative selection in CD28-deficient mice.  Cell. Immunol. 187:131-138, 1998.
  • Alegre ML, Shiels H, Thompson CB, Gajewski TG.  Expression and function of CTLA4 in Th1 and Th2 cells.  J. Immunol. 161:3347-3356, 1998.
  • Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, Neveu MJ, Bluestone JA, Thompson CB.  Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.  J. Immunol. 162:1270-1277, 1999.
  • Wissing M, Desalle F, Abramowicz D, Willems F, Leo O, Goldman M, Alegre ML.  The administration of an anti-CD3 mAb in mice differentially regulates the production of cytokines upon restimulation: implications for allogeneic skin graft survival.  Transplantation 68:677-684, 1999.
  • Muraille E, De Smedt T, Andris F, Desalle F, Goldman M, Alegre M, Urbain J, Moser M, Leo O.  Downregulation of antigen presenting cell functions following administration of mitogenic anti-CD3 monoclonal antibodies.  Blood 94:4347-4357, 1999.
  • Frauwirth KA, Alegre ML, Thompson CB.  Induction of T cell anergy in the absence of CTLA-4/B7 interaction.  J. Immunol. 164:2987-93, 2000.
  • Xu D, Alegre ML, Varga SS, Rothermel AL, Collins AM, Pulito VL, Hanna LS, Dolan KP, Parren PW, Bluestone JA, Jolliffe LK, Zivin RA.  In vitro characterization of five humanizedOKT3 effector function variant antibodies.  Cellular Immunol., 200:16-26, 2000.
  • Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML.  Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.  J. Immunol., 165:5580-5587, 2000.
  • Kouki T, Sawai Y, Gardine C, Fisfalen ME, Alegre ML, DeGroot LJ.  CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Grave’s disease.  J. Immunol., 165:6606-6611, 2000.
  • Gajewski TF, Fallarino F, Chang C, Rivas F, Shiels H, Fields PE, Alegre ML.  Absence of CTLA-4 lowers the threshold of primed CD8+ TCR transgenic T cells.  J. Immunol., 166:3900-3907, 2001.
  • Szot GL, Zhou P, Rulifson I, Wang J, Guo Z, Kim O, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML.  Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.  Am. J. Transplantation, 1:38-46, 2001.
  • Z Guo, Meng L, Kim O, Wang J, Hart J, He G, Alegre ML, Thistlethwaite JR, Newell KA.  CD8 T cell mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulation pathway.  Transplantation, 71:1351-1354, 2001.
  • Frauwirth KA, Alegre ML, Thompson CB.  CTLA-4 is not required for induction of CD8+ T cell anergy in vivo.  J. Immunol., 167:4936-41, 2001.
  • Z Guo, Wang J, Meng L, Wu Q, Kim O, Hart J, He G, Zhou P, Thistlethwaite, Jr JR, Alegre ML, Fu YX, Newell KA.  CUTTING EDGE : Membrane lymphotoxin regulates CD8+ T cell-mediated intestinal allograft rejection.  J. Immunol., 167:4796-800, 2001.
  • Chin R. Zhou P, Alegre ML, Fu YX.  Confounding factors complicate conclusions in aly model.  Nature Medicine (letter), 7:1165, 2001.
  • Hwang KW*, Sweatt WB*, Brown IE, Blank C, Gajewski TF, Bluestone JA, Alegre ML.   CUTTING EDGE: Targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.  J. Immunol., 169:633-637, 2002 (*co-first authors).
  • Harlin H, Hwang KW, Palucki D, Kim O, Thompson CB, Boothby M, Alegre ML.  CTLA-4-engagement regulates NF-B activation in vivo.  Eur. J. Immunol., 32:2095-2104, 2002.
  • Harlin H, Podack E, Boothby M, Alegre ML.  TCR-independent CD30 signaling selectively induces IL-13 production via a TRAF/p38 MAPK-dependent mechanism.  J. Immunol., 169:2451-2459, 2002.
  • Utset TO, Auger JA, Peace D, Zivin RA, Xu D, Jolliffe L, Alegre ML, Bluestone JA, Clark MR. Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial.  J. Rheumatol., 29:1907-1913, 2002.
  • Tang Q, Smith JA, Szot G, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA.  CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.  J. Immunol., 170:1510-1516, 2003.
  • Zhou P, Hwang. KW, Palucki DA, Guo Z, Boothby M, Newell KA, Alegre ML.  Impaired NF-B activation permits tolerance to primary heart allografts and secondary skin grafts.  Am. J. Transplant., 3:139-147, 2003.
  • Zhou P, Hwang KW, Palucki DA, Kim O, Newell KA, Fu YX, Alegre ML.  Secondary lymphoid organs are important but not absolutely required for allograft responses.  Am. J. Transplant., 3:359-366, 2003.  Accompanying editorial by F. Lakkis. Where is the alloimmune response initiated? 3:241-242.
  • Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim KC, Dai X, Alegre ML, Grosveld F, Fuchs E.  Gata 3: an unexpected regulator of cell lineage determination in skin.  Genes and Development, 17:2108-2122, 2003.
  • Fallarino F, Grohmann U, Hwang KW, Orabona C, Vacca C, Bianchi R, Belladonna ML, Fioretti MC, Alegre ML, Puccetti P.  Modulation of tryptophan catabolism by regulatory T cells.  Nature Immunology, 4:1206-1212, 2003.  Accompanying editorial by Karen Honey.
  • Rivas FV, O'Keefe JP, Alegre ML, Gajewski TF. The actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration. Mol. Cellular Biol., 24:1628-1639, 2004.
  • Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA, Sun Y, Chen L, Wang Y, Alegre ML*, Fu YX*.  B7-H1 costimulation promotes T cell-mediated autoimmune diabetes and islet transplantation rejection. J. Clin. Invest., 113:694-700, 2004 (* co-last authors).  Articled featured in the JCI highlights and in the Nature Reviews in Immunology highlights.
  • O’Keefe JP, Blaine K, Alegre ML, Gajewski TF.  cSMAc formation is not required for activation of naïve CD8+ T cells.  Proc. Natl. Acad. Sci. U.S.A., 101:9351-9356, 2004.
  • Hwang KW, Sweatt WB, Mashayekhi M, Palucki DA, Sattar H, Chuang E, Alegre ML.  Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice.  J. Immunol., 173:5415-5424, 2004.
  • Li D, Gal I, Vermes C, Alegre ML, Chong AS, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J.  CUTTING EDGE: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.  J. Immunol., 173:7135-7139, 2004.
  • Zhou P*, Balin SJ*, Mashayekhi M, Hwang KW, Palucki DA, Alegre ML.  T cell depletion but not T cell regulation plays a role in transplantation tolerance in mice with reduced T cell-intrinsic NF-B activation.  J. Immunol., 174:3447-53, 2005. (*co-first authors).
  • Vijayan S*, Zhou P*, Rajapaksha TW, Alegre ML, Peter ME. Transplanted islets from lpr mice are resistant to autoimmune destruction in a model of streptozotocin-induced type I diatetes.  Apoptosis, 10:725-730, 2005. (*co-first authors).
  • Lo JC, Basak S, James ES, Quiambo R, Kinsella MC, Alegre ML, Franzoso G, Hoffmann A, Fu YX.  Coordination between NF-B family members p50 and p52 is essential for mediating LTR signals in the development and organization of secondary lymphoid tissue.  Blood, 107:1048-55, 2006.
  • McNerney ME*, Lee KM*, Zhou P*, Molinero L, Mashayekhi M, Guzior D, Sattar H, Kuppireddi S, Wang CR, Vinay Kumar*, Alegre ML*.  Role of NK cell subsets in cardiac allograft rejection.  Am. J. Transplant., 6:505-513, 2006 (*co-first and co-last authors).
  • Chen L, Wang T, Zhou P, Ma L, Yin D, Shen J, Molinero L, Nozaki T, Phillips T, Uematsu S, Akira S, Wang CR, Fairchild RL, Alegre ML*, Chong A*.  TLR engagement prevents transplantation tolerance. Am. J. Transplant., 6:2282-2291, 2006.  (*co-last authors).  Editorial by S. Gangappa, CP Larsen and TC Pearson, Alloimmunity: no Toll exemption. Am. J. Transpl. 7:3-4, 2007.
  • Wang J, Dong J, Sun J, Taylor R, Guo Z, Lakkis F, Alegre ML, Williams I, Newell KA.  Donor lymphoid organs are a major site of alloreactive T cell priming following intestinal transplantation.  Am. J. Transplant., 6:505-513, 2006.
  • Vilimas T, Mascarenhas J, Mandal M, Buonamici S, Palomero T, Meng F, Macaroun S, Alegre ML, Ferrando A, Kee B, Miele L, Aifantis I.  Targeting the NF-B signaling pathway in Notch1-induced T cell leukemia.  Nature Medicine, 13:70-77, 2007.
  • Chen L, Hussien Y, Hwang KW, Wang Y, Zhou P, Alegre ML.  Overexpression of PD-1 in T cells has mild impact on allograft survival.  Transplant Int., 1:21-29, 2008.  Editorial by J. Popoola and M. Sayegh: Harnessing negative T cell costimulatory pathways to promote engraftment.
  • Molinero LL, Zhou P, Wang Y, Harlin H, Cosmano J, Yokota Y, Kee B, Abraham C, Alegre ML.  Epidermal Langerhans cells play a major role in skin allograft rejection in mice with NF-kB-impaired T cells.  Am. J. Transplant., 1:21-31, 2008.  PMCID: PMC2829624.  Editorial by R.L. Fairchild: Jump-starting alloreactive T cells with high-activation thresholds-donor Langerhans cells provide the charge.
  • Qiao G, Li Z, Molinero L, Alegre ML, Ying H, Sun Z, Penninger JM, Zhang J.  T cell receptor-induced NF-kB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.  Mol. Cel. Biol., 28:2470-80, 2008.
  • Wang T, Chen L, Ahmed E, Zhou P, Alegre ML*, Chong AS*.  Prevention of transplantation tolerance by bacterial infection with Listeria monocytogenesJ. Immunol., 180:5991-5999, 2008. (* co-last authors). Front Cover of the JI issue. NIHMS81099
  • Manicassamy S, Yin D, Zhang Z, Molinero LL, Alegre ML, Sun Z. A critical role for PKC--mediated T cell survival in cardiac allograft rejection.  J. Immunol., 181:513-520, 2008.
  • Zimmer MI, Nguyen HP, Wang B, Xu H, Colmone A, Felio K, Choi HJ, Zhou P, Alegre ML, Wang CR.  Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.  PNAS, 106:1909-1914, 2009.
  • O’Neill S, Veselits M, Zhang M, Labno C, Cao Y, Finnegan A, Uccellini M, Alegre M, Cambier JC, Clark M.  Endocytic sequestration of the B cell antigen receptor and Toll-like receptor 9 in anergic cells.  PNAS, 106(15):6262-7, 2009.
  • Song J, Volkov S, Shea CR, Alegre ML, Salgia R, Gregg K, Curran JJ, Woodruff J, Krausz T, Levine JS,Sweiss NJ.  Nephrogenic systemic fibrosis associated with stromal and vascular calcification, report of 2 cases.  J. Cutan. Pathol., 36, suppl. 1:31034, 2009.
  • Molinero LL, Wang Y, Zhou P, Yagita H, Alegre ML.  Fas mediates cardiac allograft acceptance in mice with impaired T cell-intrinsic NF-kB signaling.  Transplant International, 22:845-852, 2009.
  • Chen L, Ahmed E, Wang T, Wang Y, Ochando J, Chong AS*, Alegre ML*.  TLR signals promote IL-6/IL-17-dependent transplant rejection.  J. Immunol., 182:6217-6225, 2009. PMCID: PMC 2834528. (* co-last authors).
  • Molinero LL, Yang J, Gajewski TF, Abraham C, Farrar MA, Alegre ML.  CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.  J. Immunol., 182: 6736 – 6743, 2009. PMCID: PMC2830151.
  • Sweiss NJ, Salloum R, Ghandi S, Alegre ML, Bordache M, Pursell K, Pitrack D, Baughman RP, Garcia J, Niewold TB.  Significant CD4, CD8 and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations.  PLOS ONE, in press 2010.
  • Wang T, Ahmed E, Chen L, Wang CR, Alegre ML, Chong AS.  Infection with the intracellular bacterium, Listeria monocytogenes overrides established allograft tolerance.  Am. J. Transplant., 10:1524-1533, 2010. Accompanying editorial by Ron Gill AJT, 10:1499-1500 “Just How Stable Is Allograft Tolerance?”
  • Bhorade S, Chen H, Molinero LL, Liao C, Garrity ER, Vigneswaran WT, Shilling R, Sperling A, Chong AS*, Alegre ML*.  Decreased percentage of CD4+FoxP3+ cells in BAL from lung transplant recipients correlates with development of BOS.  Transplantation, 90:540-546, 2010.  (*co-last authors).
  • Kim AS, Stanley S, Zhou P, Goenka S, Hulbert C, Adeeku E, Thomas JW, Alegre ML, Boothby M.  Essential role of NF-kB inducibility in T cells for immune attack on pancreatic islets. Manuscript submitted.
  • Ahmed EB, Wang T, Tao J, Alegre ML, Chong AS.  IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.   Am. J. Transplant., 11:936-946, 2011.
  • Molinero LL, Miller ML, Evaristo C, Alegre ML.  High TCR Stimuli Prevent iTreg Differentiation in an NF-kB-Dependent Manner.  J. Immunol., 186: 4609-4617, 2011. Featured in the “In This Issue” article highlights.
  • Lozano Porras D, Wang Y, Molinero LL*, Alegre ML*.  Role of T cell-specific NF-kB in islet allograft rejection.  Transplantation, in press, 2012. (*co-last authors).

Book Chapters

  • Goldman M, Abramowicz D, Alegre ML.  Acute allograft rejection: immunobiology and therapeutic strategies.  Yearbook of Intensive Care and Emergency Medicine, Erasmus Hospital, Brussels, 1992.
  • Alegre ML, Noel PJ, Chuang E, Thompson,CB. The role of CD28 and CTLA4 in immune responses.  Immune Tolerance, Elsevier Press, Blanchereau J, Dodet B, Schwarz R, Trannoy E:187-196,1996.
  • Alegre ML.  Monoclonal antibodies in transplantation.  Antibody Therapeutics, CRC Press, Harris WJ, Adair, JR:137-166, 1997.
  • Alegre ML, Gajewski TF, Thompson CB. Second signals for lymphocyte activation, Encyclopedia of Immunology, 2nd edition, 2145-2151, 1998.
  • Gajewski TF, Alegre ML.  T cell responses.  Encyclopedia of Life Sciences, 2000, http://www.els.net/els/els/els/index.html?sessionid=688117e282a96501.
  • Alegre ML, Bluestone JA.  T-cell antigen and costimulatory receptors as therapeutic targets. Lippincott Williams & Wilkins, 6th edition, 2001.
  • Alegre ML, Gajewski TF.  CTLA-4: its role in the immune response.  CTLA-4 in autoimmune diseases, Landes Bioscience, 2001.

Review Articles

  • Alegre ML, Lenschow DJ, Bluestone JA.  Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors.  Digestive Dis. and Sci., 40:58-64, 1995.
  • Alegre ML.  Costimulatory molecules as targets for the induction of transplantation tolerance.  Nephrology Dialysis Transplantation, 14:322-332, 1999.
  • Alegre ML, Frauwirth KA, Thompson CB.  T cell regulation by CD28 and CTLA-4.  Nature Reviews in Immunology, 1:220-228, 2001.
  • Alegre ML.  Targeting NF-kB in the immune system to prevent acute allograft rejection.  Curr. Opin. Organ Transpl., 9:252-257, 2004.
  • Brown I, Mashayekhi M, Alegre ML, Gajewski TF.  Survival of naïve CD8+ T cells. Apoptosis, 10:5-11, 2005.
  • Subudhi S, Alegre ML, Fu YX.  Role of B7-H1 in immune responses in vivo.  J. Molecular Medicine, Jan 4; 83:193-202, 2005.
  • Fallarino F, Alegre ML.  Mechanisms of CTLA-4-Ig in tolerance induction.  Current Pharmaceutical Design, 12:149-160, 2006.
  • Alegre ML, Najafian N.  Targeting costimulatory molecules for the induction of transplantation tolerance. Current Molecular Medicine, 6:843-57, 2006.
  • Alegre ML, McNerney M.  NK cell subsets in allograft rejection and tolerance.  Current Opinions in Organ Transplantation, 12:10-16, 2007.
  • Alegre ML, Florquin S, Goldman M.  Cellular mechanisms underlying graft rejection: time for reassessment.  Current Opinions in Immunology, 19:563-568, 2007.
  • Ahmed E., Alegre ML, Chong AS.  The role of bacterial infections in allograft rejection, Expert Review of Clinical Immunology, in press, 2008.
  • Alegre ML, Chong AS.  TLR signals in transplantation immunology.  Frontiers in Bioscience, in press, 2008.
  • Alegre ML, Leemans J, Le Moine A, Florquin S, Chong AS, Goldman M. The multiple facets of toll-like receptors in transplantation biology.  Transplantation, 86:1-9, 2008.  Front cover of the Transplantation issue.
  • Alegre ML, Goldstein DR, Chong AS.  TLR signaling in transplantation, Current Opinions in Transplantation, 13:358-365, 2008.
  • Alegre ML, Chen L, Wang T, Ahmed E, Wanh CR, Chong A.  The impact of TLR signaling and bacterial infections on transplantation tolerance.  Transplantation, 87(9 Suppl):S77-9, 2009. PMCID: PMC2740905
  • Ahmed EB, Daniels, M, Alegre ML, Chong AS.  Bacterial infections, alloimmunity and transplantation tolerance.  Transplantation Reviews, 25:27-35, 2011.
  • Molinero LL, Alegre ML.  NF-kB in transplantation.  Transplantation Reviews, 2011, in press.
  • Alegre ML, Fu YX.  Attenuation by targeting the B and T cell attenuator (BTLA).  Commentary in Transplantation, 92:1075-62011, 2011.
  • Alegre ML, Chong AS.  “Tip-toeing” to an assay for transplantation tolerance?  Editorial in American Journal of Transplantation, 2011, doi: 10.1111/j.1600-6143.2011.03871.x.
  • Alegre ML, Bromberg J.  The anti-infectious role of the IL-17 pathway.  Literature WatchAmerican Journal of Transplantation, January 2012.
  • Alegre, ML, Chong AS. Costimulatory molecules and Toll-like receptors in transplantation.  American Society of Transplantation Handbook of Transplant Immunology, Wiley-Blackwell, 2012, in press.